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Artificial Leaf Produces First Drugs Using Sunlight

An anonymous reader quotes a report from New Atlas: Making artificial versions of the humble leaf has been an ongoing area of research for decades and in a new breakthrough, researchers from the Eindhoven University of Technology (TUE) have fine-tuned their artificial leaf design and used it to produce drugs for the first time. Natural leaves are clever little machines. They collect sunlight, and that energy is then used by chlorophyll molecules to power a chemical reaction that turns CO2 and water into glucose. The plant uses this glucose for energy, and expels oxygen as a waste product. Artificial leaves are designed to mimic this process. They’re made of translucent materials that allow sunlight in and direct it towards tiny microfluidic channels running through the material like veins. A certain liquid is flowing through these channels, and the idea is that the energy from the sunlight triggers a chemical reaction in that liquid, turning it into something useful like a drug or fuel.

The new artificial leaf design from TUE builds on the team’s previous prototype, presented in 2016. Back then, the device was made of silicon rubber, but in the new version that’s been replaced with Plexiglas for several reasons. [The material is cheaper and easier to manufacturer in larger quantities, has a higher refractive index, and can contain more types of light-sensitive molecules.] The leaf has started to earn its keep, too. The team put it to the test and found that it was able to successfully produce two different drugs: artimensinin, which is effective against malaria, and ascaridole, which is used against certain parasitic worms. Given its small size and scalability, the team says that the artificial leaf could eventually be used to produce drugs and other molecules right where they’re needed. The research was published in the journal Angewandte Chemie.


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